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Methotrexate: Uses, Active Ingredient, and Difference Between Generic Methotrexate

What is Methotrexate?

Methotrexate is a medication used to treat certain types of cancer, rheumatoid arthritis, and psoriasis. It works by slowing down or stopping the growth of cells that are dividing rapidly.

Active Ingredient

Methotrexate contains the active ingredient methotrexate sodium, which belongs to a group of drugs called antimetabolites.

Generic Methotrexate

Generic Methotrexate contains the same active ingredient as the brand-name drug Methotrexate. The only difference between the two is the manufacturer and the price.

Instructions for Use

Description of the Medication

Methotrexate comes in tablet and injectable forms. The tablets are available in strengths of 2.5, 5, 7.5, and 10 mg, while the injectable form comes in 25 mg/mL vials.

Packaging

Methotrexate tablets are typically sold in blister packs of 30 or 100 tablets, while the injectable form is sold in single-use vials.

Composition

The active ingredient in Methotrexate is methotrexate sodium. The tablets also contain inactive ingredients such as lactose, starch, and magnesium stearate.

Pharmacological Action

Methotrexate works by inhibiting the growth of cells that are dividing rapidly. This makes it effective in treating cancer, rheumatoid arthritis, and psoriasis.

Dosage

The dosage of Methotrexate will vary depending on the condition being treated. It is important to follow the instructions provided by your doctor or pharmacist.

Precautions

Methotrexate should be used with caution in patients with liver or kidney disease, as well as those with a history of alcoholism or immunodeficiency disorders.

Contraindications

Methotrexate is contraindicated in pregnant women, breastfeeding mothers, and patients with a known hypersensitivity to the drug.

Side Effects

Common side effects of Methotrexate include nausea, vomiting, and mouth sores. More serious side effects include liver damage and decreased bone marrow function.

Drug Interactions

Methotrexate can interact with a variety of drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), penicillins, and probenecid.

Overdose

Overdose of Methotrexate can lead to serious side effects, including kidney damage and bone marrow suppression. Seek medical attention immediately if you suspect an overdose.

Analogs

There are several analogs of Methotrexate available, including Leflunomide and Azathioprine.

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Disclaimer

The information provided in this article is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.