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Indocin: Uses, Active Ingredient, and More

Indocin is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, swelling, and stiffness caused by conditions like arthritis, gout, and ankylosing spondylitis. The active ingredient in Indocin is indomethacin, which works by reducing the production of certain chemicals in the body that cause inflammation and pain.

Description and Packaging

Indocin comes in the form of capsules and suppositories. The capsules are available in 25mg and 50mg strengths, while the suppositories come in 50mg strength. The capsules are usually sold in bottles of 100 or 500, while the suppositories are sold in boxes of 10 or 50.

Pharmacological Action and Dosage

Indomethacin is a non-selective inhibitor of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. By inhibiting the activity of COX enzymes, Indocin reduces the production of prostaglandins and other inflammatory mediators. The recommended dose of Indocin for adults is 25mg to 50mg two to three times daily.

Precautions, Contraindications, and Side Effects

Indocin should be used with caution in patients with a history of peptic ulcer disease, liver or kidney disease, or heart failure. It is contraindicated in patients with a history of hypersensitivity to indomethacin or other NSAIDs. Common side effects of Indocin include stomach pain, nausea, and headache. Rare but serious side effects include bleeding, ulcers, and kidney damage.

Interactions with Other Drugs

Indocin may interact with other drugs, such as anticoagulants, diuretics, and lithium. It should not be taken with other NSAIDs or aspirin, as this can increase the risk of side effects.

Overdose and Analogs

In case of overdose, immediate medical attention should be sought. There are several analogs of Indocin available, including Naproxen, Ibuprofen, and Diclofenac.

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Disclaimer: The information provided in this article is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.