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Cephalexin - an Antibiotic Used to Treat Infections

What is Cephalexin?

Cephalexin is an antibiotic medication that is used to treat a variety of bacterial infections such as respiratory tract infections, skin infections, and urinary tract infections. It belongs to a class of drugs known as cephalosporin antibiotics.

Active Ingredient

The active ingredient in Cephalexin is cephalexin monohydrate, which is a semi-synthetic, first-generation cephalosporin antibiotic.

Description

Cephalexin comes in the form of capsules or tablets, with a strength of 250mg or 500mg. It is usually taken orally every 6 hours, with or without food.

Composition

Each capsule of Cephalexin contains cephalexin monohydrate equivalent to 250mg or 500mg cephalexin. Inactive ingredients include magnesium stearate, microcrystalline cellulose, and gelatin.

Pharmacological Action

Cephalexin works by inhibiting the bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the inhibition of the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. This leads to the weakening of the bacterial cell wall, which eventually leads to bacterial cell lysis and death.

Dosage

The dosage of Cephalexin depends on the severity of the infection, the patient's age, weight, and renal function. The usual dose for adults is 250mg every 6 hours or 500mg every 12 hours. The duration of the treatment depends on the type and severity of the infection.

Precautions

Cephalexin should be used with caution in patients with a history of penicillin allergy or cephalosporin allergy. Patients with renal impairment should be monitored closely, and the dosage should be adjusted accordingly.

Contraindications

Cephalexin is contraindicated in patients with known hypersensitivity to cephalexin or any other component of the drug.

Side Effects

The most common side effects of Cephalexin include diarrhea, nausea, vomiting, and abdominal pain. Other side effects include skin rash, itching, and hives. If any of these side effects persist or worsen, the patient should contact their healthcare provider immediately.

Drug Interactions

Cephalexin may interact with certain medications such as probenecid and metformin. It is important to inform the healthcare provider of all medications, including over-the-counter drugs, vitamins, and herbal supplements, before starting Cephalexin.

Overdose

Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, the patient should contact their healthcare provider immediately or seek emergency medical attention.

Analogs

Some analogs of Cephalexin include Cefadroxil, Cefalexin, Cefazolin, and Cefotaxime.

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