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Bactrim: What is it?

Bactrim is a combination of two antibiotics, sulfamethoxazole and trimethoprim, which are used to treat a wide range of bacterial infections, including urinary tract infections, ear infections, bronchitis, and traveler's diarrhea. It works by inhibiting the production of folic acid in bacteria, which is necessary for their growth and survival.

Description and Packaging

Bactrim is available in tablet form and as an oral suspension. The tablets are oval, white, and scored, with "Bactrim" engraved on one side and "DS" on the other. The oral suspension is a pink, cherry-flavored liquid supplied in bottles of 100 mL.

Pharmacological Action and Dosage

Bactrim's antibacterial activity results from the inhibition of dihydrofolate reductase and nucleic acid synthesis in susceptible bacteria. The recommended dosage for adults with bacterial infections is 1-2 Bactrim DS (double strength) tablets or 20 mL of the oral suspension every 12 hours for 10-14 days. The dosage may need to be adjusted for children and individuals with kidney or liver disease.

Precautions and Contraindications

Bactrim should be used with caution in patients with a history of allergy or hypersensitivity to sulfonamides, trimethoprim, or other antibiotics. It may also cause severe adverse reactions in patients with renal or hepatic impairment. Bactrim should not be used in pregnant women, nursing mothers, or infants under two months of age.

Side Effects and Interactions

Bactrim may cause side effects such as nausea, vomiting, diarrhea, skin rash, fever, or anemia. It may also interact with other drugs, including blood thinners, diuretics, and anticonvulsants. Patients should inform their healthcare provider of all medications they are taking before starting Bactrim.

Overdose and Analogues

Overdose with Bactrim may cause symptoms such as nausea, vomiting, dizziness, and confusion. Treatment involves discontinuing the medication and providing supportive care. Analogues of Bactrim include Septra, Cotrim, and Sulfatrim.

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