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Assurans: What is it and how to use it?

Description

Assurans is a medication that belongs to a group of drugs called phosphodiesterase type 5 inhibitors. It is primarily used to treat pulmonary arterial hypertension (PAH), a condition that causes high blood pressure in the arteries of the lungs. Assurans works by relaxing the blood vessels in the lungs, allowing the blood to flow more easily, thus decreasing the high blood pressure in the lungs and improving the patient's ability to exercise.

Formulation and Packaging

Assurans is available in tablet form in two strengths: 20mg and 40mg. The tablets are packed in blister packs, each containing 4 tablets.

Composition

The active ingredient in Assurans is sildenafil citrate. Each tablet contains either 20mg or 40mg of sildenafil citrate, along with several inactive ingredients such as microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose monohydrate, triacetin, and FD&C Blue #2 aluminum lake.

Pharmacological Action

Sildenafil citrate, the active ingredient in Assurans, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This results in increased levels of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle cells in the blood vessels, allowing them to dilate and increase blood flow to the lungs. This, in turn, leads to decreased pulmonary arterial pressure and improved exercise capacity in patients with PAH.

Dosage and Administration

The recommended dose of Assurans is 20mg taken three times daily, approximately 4 to 6 hours apart. The tablets should be swallowed whole with water, and should not be crushed or chewed. The dosage may be adjusted based on the patient's response to the medication and their overall health. It is important to follow the dosage instructions provided by the healthcare provider.

Precautions and Contraindications

Assurans should not be taken by patients who are allergic to sildenafil citrate or any of the other ingredients in the medication. It should also not be taken with any medications that contain nitrates, as this can cause a sudden and serious drop in blood pressure. Patients with severe liver or kidney problems should use the medication with caution, and a reduced dosage may be required. Assurans should not be taken by women who are pregnant or breastfeeding.

Side Effects and Interactions

Common side effects of Assurans include headache, nausea, flushing, dizziness, and diarrhea. These side effects usually go away on their own, but if they persist or become severe, medical attention should be sought. Assurans can also interact with certain medications, such as other medications used to treat PAH, antifungal medications, and antibiotics. It is important to inform the healthcare provider of all medications being taken before starting Assurans.

Overdose

In case of overdose, seek immediate medical attention. Symptoms of an overdose may include severe dizziness, fainting, or priapism (a painful erection that lasts longer than 4 hours).

Analogs

Assurans is a generic version of the medication Revatio, which is also used to treat pulmonary arterial hypertension. Other analogs of Assurans include Viagra, Cialis, and Levitra, which are also phosphodiesterase type 5 inhibitors used to treat erectile dysfunction. However, it is important to note that these medications are not approved for the treatment of PAH and should not be used in place of Assurans without the recommendation of a healthcare provider.

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