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What is Allopurinol?

Allopurinol is a medication used to treat gout and kidney stones. It works by reducing the amount of uric acid produced in the body. High levels of uric acid can cause gout and kidney stones. Allopurinol is available only with a prescription from a healthcare provider.

Formulation and Packaging

Allopurinol is available in tablet form and is packaged in 100mg and 300mg strengths. The tablets are white, round, and biconvex in shape. Each tablet contains the active ingredient allopurinol and inactive ingredients such as lactose, magnesium stearate, and povidone.

Pharmacological Action

Allopurinol works by inhibiting the production of uric acid in the body. It does this by blocking the enzyme xanthine oxidase, which is responsible for converting purines into uric acid. By reducing the amount of uric acid in the body, allopurinol can prevent the formation of uric acid crystals that cause gout and kidney stones.

Dosage and Administration

The dosage of allopurinol varies depending on the condition being treated and the patient's age, weight, and other factors. Typically, the recommended starting dose is 100mg to 300mg per day, taken orally. The dosage may be increased or decreased based on the patient's response to treatment.

Precautions and Contraindications

Allopurinol should not be taken by individuals who are allergic to allopurinol or any of its ingredients. It should also be avoided by individuals with a history of severe liver or kidney disease. Before taking allopurinol, patients should inform their healthcare provider of any other medical conditions or medications they are taking.

Side Effects

Common side effects of allopurinol include nausea, vomiting, diarrhea, headache, and drowsiness. More serious side effects may include rash, fever, joint pain, and difficulty breathing. Patients who experience any of these side effects should contact their healthcare provider immediately.

Drug Interactions

Allopurinol may interact with other medications, including azathioprine, mercaptopurine, and theophylline. Patients should inform their healthcare provider of any other medications they are taking before starting allopurinol.

Overdose

In the event of an overdose, patients should seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, diarrhea, dizziness, and difficulty breathing.

Analogues

There are several analogues to allopurinol, including febuxostat and probenecid. Patients should consult with their healthcare provider to determine which medication is most appropriate for their needs.

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